Mesothelin and osteopontin

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Mesothelin and osteopontin

The review by PANTAZOPOULOS et al. [1] on mesothelin and osteopontin was timely and well written. However, I would like to comment on some of the statements that were made. Firstly, it states that ‘‘patients with early-stage disease can survive for more than 5 years if the tumour is promptly resected’’. This implies that resection would benefit the patient, which is far from proven; there is no...

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Mesothelin and osteopontin.

The review by PANTAZOPOULOS et al. [1] on mesothelin and osteopontin was timely and well written. However, I would like to comment on some of the statements that were made. Firstly, it states that ‘‘patients with early-stage disease can survive for more than 5 years if the tumour is promptly resected’’. This implies that resection would benefit the patient, which is far from proven; there is no...

متن کامل

Effectiveness of mesothelin family proteins and osteopontin for malignant mesothelioma.

Malignant mesothelioma (MM) is an aggressive tumour with poor prognosis whose early diagnosis is difficult. Mesothelin, megakaryocyte potentiating factor (MPF) and osteopontin have attracted attention as biomarkers. The aim of the present review is to provide an overview regarding these candidate biomarkers for MM, and discuss their potential role in today's clinical practice. Mesothelin and MP...

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Utility of osteopontin and serum mesothelin in malignant pleural mesothelioma diagnosis and prognosis assessment.

PURPOSE Malignant mesothelioma is a highly aggressive tumor and is often diagnosed too late for a curative treatment. We compared diagnostic and prognostic values of mesothelin and osteopontin in 172 patients suspected of malignant pleural mesothelioma (MPM) and in a control group of 112 asymptomatic asbestos-exposed subjects. EXPERIMENTAL DESIGN Osteopontin and mesothelin were assayed with c...

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Impact of renal failure on the tumor markers of mesothelioma, N-ERC/mesothelin and osteopontin.

BACKGROUND Knowledge of the characteristics and effective use of tumour markers for mesothelioma is essential for early-stage diagnosis of mesothelioma. We examined whether renal dysfunction influences blood concentrations of promising new tumour markers, N-ERC/mesothelin (N-ERC) and osteopontin (OPN), to an important degree. PATIENTS AND METHODS Levels of serum N-ERC and plasma OPN in 32 pat...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2013

ISSN: 0903-1936,1399-3003

DOI: 10.1183/09031936.00052213